Objective: To explore influence discipline of chitosan flocculation clarification and alcohol precipitation for aqueous solution of Yiganning compound. Method: Sample was investigated by multi-indexes to evaluate difference of two purification methods for aqueous solution of Yiganning compound

such as yield of extracts

physic liquor clarity

the content of carbohydrate(polyose

monosaccharide

oligosaccharide) and three active component(peoniflorin

salvianolic acid B and paeonol)

moisture absorption ratio. Result: Yield of extracts of ethanol precipitation samples was close to chitosan clarification samples.Physic liquor clarity

transfer rate of carbohydrate and paeoniflorin of ethanol precipitation samples was lower than chitosan clarification samples

while transfer rate of salvianolic acid B and paeonol of ethanol precipitation samples are higher than chitosan clarification samples.Extracts hygroscopicity of ethanol precipitation samples are higher than chitosan clarification samples. Conclusion: The result provided a feasible method for investigating purification process of herbal extract preparation

and could be used for purification preparation craft optimization of herbal praeparatum.