茶碱-环糊精聚合物微球的制备与缓释性能

杨黎燕; 杨威; 尤静; 张静姝

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茶碱-环糊精聚合物微球的制备与缓释性能

更新时间：2024-01-04

- 茶碱-环糊精聚合物微球的制备与缓释性能
- Preparation and Sustained Release of Theophylline -Cyclodextrin Polymer Microspheres Inclusion Compound
- 中国实验方剂学杂志 2011年17卷第16期页码：8-12
- 作者机构：
- 作者简介：
- 基金信息：
  
  陕西省教育厅科研计划项目(11JK0694);西安医学院校级科研基金项目(10FC021)
- DOI：
  中图分类号：
- 纸质出版日期：2011
- 稿件说明：
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杨黎燕, 杨威, 尤静, 等. 茶碱-环糊精聚合物微球的制备与缓释性能[J]. 中国实验方剂学杂志, 2011,17(16):8-12.

YANG Li-yan, YANG Wei, YOU Jing, et al. Preparation and Sustained Release of Theophylline -Cyclodextrin Polymer Microspheres Inclusion Compound[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 8-12.
杨黎燕, 杨威, 尤静, 等. 茶碱-环糊精聚合物微球的制备与缓释性能[J]. 中国实验方剂学杂志, 2011,17(16):8-12. DOI：

YANG Li-yan, YANG Wei, YOU Jing, et al. Preparation and Sustained Release of Theophylline -Cyclodextrin Polymer Microspheres Inclusion Compound[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 8-12. DOI：

摘要

目的: 以β-环糊精为原料

采用共沉淀法制备茶碱β环糊精聚合物(CDP)微球。方法: 通过L9(34)正交试验设计对制备工艺进行了优化

并采用体外动态释药法评价其释药特征。分别用激光粒度分布仪、红外光谱仪、综合热分析仪、X射线衍射仪对茶碱β-CDP载药微球进行表征。结果: 最佳工艺条件是β-CDP微球1 g、茶碱 0.02 g、蒸馏水30 mL、反应时间3 h、温度60 ℃。合成的载药微球形态良好

平均粒径为 162.35 μm

载药量为1.79%

包封率为89.50%。茶碱β-CDP微球体外释药规律符合一级释放方程和Korsmeyer-Peppas模型方程。结论: 茶碱载药微球具有一定缓释效果

其制备方法合理可行。

Abstract

Objective: Theophylline β-cyclodextrin polymer(β-CDP) microspheres inclusion compound was prepared with β-cyclodextrin as material by coprecipitation method. Method: The preparation process was optimized through the L9(34) orthogonal experimental design and theophylline release from theophylline β-cyclodextrin polymer microspheres was evaluated in vitro.Theophylline β-cyclodextrin polymer microspheres was characterized by laser particle analyzer

FT-IR spectroscopy

thermogravimetric analysis (TGA) and X-ray diffraction (XRD). Result: The optimal procedure was β-CDP microspheres 1 g

theophylline 0.02 g

water 30 mL

time 3 h

and inclusion temperature 60 ℃. Average diameter of optimized products was 162.35 μm and the drug loading and drug encapsulation efficiency were 1.79% and 89.50% respectively. The drug release profile could be described by first-order release equation and Korsmeyer-Peppas equation. Conclusion: The sustained release microspheres had determinate effects be observed and this preparation method was reasonable and feasible.

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