Objective: To study the antitussive

expectorant and antibacterial effects of Zhebei Zhike granules. Method: Mice were divided into 5 groups randomly: Normal saline (NS) group

positive group

high dose group

middle dose group and low dose group of Zhebei Zhike granules (24.4

12.2

6.1 g·kg-1)

after 6 d by ig administration

the antitussive effect was studied by the cough model induced by ammonia in mice

the expectorant effect was studied by a mouse model of phenol red test. Rats were divided into 5 groups randomly: NS group

positive group

high dose group

middle dose group and low dose group of Zhebei Zhike granules (18.4

9.2

4.6 g·kg-1)

after 6 d by ig administration

the expectorant effect was studied by testing the amount of phlegm secreted in rats. Experimental research on antibacterial action of Zhebei Zhike granules was applied to observe the antibacterial effect. Result: The experimental results showed that high dose group and middle dose group of Zhebei Zhike granules could produce a protective effect on the cough induced by ammonia (P<0.01)

increase phenol red excretion in mice and phlegm expelling in rats (P<0.05 or P<0.01). The granules showed obvious antibacterial actions against Staphylococcus aureus (the diameter of inhibition zone is 14mm

MIC is 3.9 mg·mL-1

MBC is 7.8 mg·mL-1) and Streptococcus pneumonia (the diameter of inhibition zone is 16mm

MIC is 15.6 mg·mL-1

MBC is 31.2 mg·mL-1)

and also showed some protective effect to mice infected with bacteria (P<0.01). Conclusion: Zhebei Zhike granules have obvious antitussive

expectorant and antibacterial actions.