Objective: To investgate the effect of Shuyu granules on monoamine neurotransmitters and inflammatory factors in hippocampus of post-stroke depression(PSD)rats. Method: PSD model was established by permanent bilateral common carotid artery ligation together with a behavior limitation. The spontaneous behavior was observed and monoamine neurotransmitters in the hippocampus and tumor necrosis factor-α(TNF-α)and interleukin 1β(IL-1β)were detected in 22 days after surgery. Result: Compared with the model group

there were significant differences in the behavior ability of PSD rats in three dose groups of Shuyu granules and Fluoxetine group(P<0.05). Compared with the model group

norepinephrine(NE)

dopamine(DA)

serotonin(5-HT) were significantly increased(P<0.05)in the three dose groups of Shuyu Granules.

IL-1β and TNF-α were significantly decreased(P<0.05). Conclusion: Shuyu granuls could increase monoamine neurotransmitters and reduce cytokines and improve the spontaneous behavior in post-stroke depression rats.