Objective: To observe the effect of Jiawei Taohe Chengqi decoction(JWTHCQD)on learning and memory in Aβ1-42 induced Alzheimer’s disease(AD)in rats and study its mechanism. Method: Rats were injected bilaterally of aggregated Aβ1-42

Aβ42-1 or PBS into hippocampus mounted using stereotaxic apparatus for AD model establishment. Three groups rats were treated with JWTHCQD(20 g·kg-1)or saline solution respectively. After 21 days

learning and memory ability of the rats were determined by Morris water maze test. And hippocampus tissue specimens for each group were harvested for Tau and p-Tau protein detcted by Western blotting. Result: In place navigation test

the time of escape latency was significantly longer in Aβ1-42 group than that in other groups(P<0.05)

but shorter in JWTHCQD treated Aβ1-42 group(P<0.05). Besides

Tau and p-Tau protein were all down-regulation in the Aβ1-42 group after JWTHCQD treatment. Conclusion: JWTHCQD could improve the learning and memory in AD model rats by regulating Tau and p-Tau protein expression.