Objective: To observe the patterns of changes in syndrome of Chinese medicine for rat model of type 2 diabetes with insulin resistance. Method : The rat model was established by feeding with high calories and fat diet together with peritoneal injection of STZ. SD rats were randomly divided into the control group (50 rats) and the model group (60 rats). The changes in appearance

behavior and weight of rats during the process of experiment were observed. At the end of the 0

6

8

10 and 12 week

ten rats each time were killed and blood samples were collected respectively to detect the (FPG) and Fins

and to calculate the insulin resistance index (IRI) and insulin sensitivity index (ISI). Result : 1) Appearance and behavior: Compared with the control group

the weight of the model group gained up obviously at 4th week

and lowers continually from the 9th week

higher obviously than that of the control group. During the 6 w to 8 w

the model rats appeared in lethargy with narrowed eyes

accidie

loss of hair

increased drinking volume

dejecta desiccation

sweatiness and wateriness at tail. During the 9 w~10 w

the model rats appeared fatness

extrados

gather together

narrowed eyes

accidie

slow action

fatness in hair which based on syndromes at first phase; during the 11-12 w

the model rats appeared continually loss of hair and turn into yellow color at stern

dark-purple tongue

and ome petechias appeared at the tail from top to root. Glucose metabolism: Compared with the control group

the FPG

Fins

IRI levels of the model group were increased continually from the end of 6th week

reached its top at the end of 12th week. The IAI level was decreased obviously from the end of 6th week

reached its bottom at the end of 12th week. Conclusion : The rat model of type 2 diabetes with insulin resistance established by feeding high calories and fat diet together with peritoneal injection of STZ may appear the characters of dynamic evolutionary syndromes in Chinese medicine during different phases. The dynamic progression of syndromes in Chinese medicine is from the simultaneous deficiency of both qi and yin to simultaneous deficiency of both qi and yin with concurrent turbid phlegm

and the lastly to the simultaneous deficiency of both qi and yin with concurrent turbid phlegm and blood stasis.