Objective: To verify the main pharmacological action of Yansheng granule. Method: The Yin-deficient mouse and rat models were set up by using warm-hot natured drugs

thyroxine and D-galactose and levothyroxine sodium

respectively

in order to observe the effect of Yansheng granule on the syndromes the pain threshold and humoral immunologic function of mouse. Result: In the Yin-deficient mouse model induced by Warm-hot natured drugs

Yansheng granule could decrease the autonomous locomotor activity

reduce Cyclic Adenosine Monophosphate (cAMP) in plasma and pain sensitivity

and enhance immunologic function. In the Yin-deficient mouse model induced by thyroxine

Yansheng

granule could significantly decrease the autonomous locomotor activity

increase body weight growth rate and reduce the growth of thymus and spleen. Yansheng granule could significantly improve whole blood viscosity of rats under low shear rate

but there was no significant influence about plasma viscosity. Conclusion: Yansheng granule could improve the symptoms of animal Yin-deficient models. The results of our experiment could provide some theoretical and experimental evidence for the clinical application of this medicine.