The article reviewed the research on in vivo process of protoberberine alkaloids by oral administration

aimed to provide reference data for the choice of dosage form

research of pharmacodynamics and toxicology

and rational use of protoberberine alkaloids. By literatrue retrieval in China Knowledge Resource Integrated Database

VIP technology journal full-text database and Foreign Medical Journal Full-Text Service

the article reviewed the progress of the gastrointestinal absorption

tissue distribution

metabolic pathway and product

excretion and the pharmacokinetic parameters of protoberberine alkaloids by oral administration. Researches of several active ingredients involved intestinal ransport mechanism and characteristic

tissue distribution

metabolism and excretion

main metabolites

orally dynamic parameters etc. In vivo process of protoberberine alkaloids by oral administration is relatively complex. Current research is not systematic enough. Drug interactions of in-vivo process is unclear

pharmacological effects of metabolites still need further confirmation.