Objective: To study the lipid-lowering effects on flavonoid-phospholipid complex from Lonicera japonica Thunb in quails fed with high lipid food. Method: Eighty quails were randomly divided into 6 groups

one normally fed control group and other 5 groups. The quails in the 5 groups were fed with high lipid food for 12 days to form hyperlipidemic model

then fed with high fat diet continuously for 45 days. During the later 45 days

the model group was fed with normal saline

the other 3 treatment groups were treated with flavonoid (20 mg ·kg-1 ·d-1)

flavonoid-phospholipid complex from L. japonica . (80 or 20 mg ·kg-1 ·d-1) accordingly. The levels of total cholesterol (TC)

triglycerides (TG)

HDL-C

LDL-C in serum and the fatty content in liver of the quails with hyperlipidemia were measured. Result: The high lipid food remarkably increased plasma content of TC (P<0.01)

TG (P<0.01) and the fatty content in liver. Flavonoid-phospholipid complex from L. japonica . could remarkably reduce TC level in serum and the degree of pathological changes in liver cells of the hyperlipidemic model. Conclusion: Flavonoid-phospholipid complex from L. japonica . has the effects on decreasing the level of serum lipids and protecting the liver against fatty accumulation.