Objective: To establish foundation for constructing a suitable animal model of deficiency of both Qi and Yin syndrome (DQYS) induced by two types of chronic intermittent hypoxia (soda lime and low-pressure oxygen controller) by comparison the whole behavior in mice. Method: The two modes of oxygen scarcity

including oxygen pressure declining continuously from 21% to 7%-8% with the average speed of 0.5%/min-1% per minute in airtight wide-mouthed bottle and oxygen pressure falling abruptly within short period and then keeping in the level of 7%-8%

were adopted respectively to observe the time-course changes in body weight

food intake

locomotive activity and electrocardiogram respectively. The experiments were designed for mimicing clinical features of DQYS. Result: The mice exposed to two different modes of chronic intermittent hypoxia for certain duration showed body weight loss

food intake decline

locomotive activity change of ambulation decrease and rearing increase

heart rate increase and T wave elevation. There was significant correlation between the results of the two groups. Conclusion: Both types of chronic intermittent hypoxia can simulate the major clinical features of DQYS mainly characterized by tiredness

emaciation

anorexia

fidget

palpitation and rapid pulse

etc.