Objective: To optimize alcohol extraction process of Anshen granules. Method: The optimum alcohol extraction conditions were investigated by orthogonal design with the content of jujuboside A and schizandrin as indexes.Determined by HPLC

using Lichrospher C18column(4.6 mm×250 mm

5 μm)

column temperature was 30 ℃

flow rate was 1.0 mL·min-1;Determined jujuboside A with CH3CN-water(30.5 ∶69.5)as mobile phase

the UV detection wavelength was 204 nm;Schizandrin were investigated with methanol-water(13 ∶7)as mobile phase

the UV detection wavelength was 250 nm. Result: The amount of ethanol and extracting time had significant effect on extraction of schizandrin.The optimum alcohol extraction technology of Schisandrae Chinensis Fructus and Ziziphi Spinosae Semen from complex prescription was as follows:extracted 2 times with 10 times amount of 85% ethanol for 1.0 h per time. Conclusion: This extraction technology is reasonable

simple and suitable for mass production.