Objective: To observe the clinical efficacy of Tangmaikang particles combined with captopril on diabetic nephropathy (DN). Method: 160 patients were randomly divided into two groups which were the observation group and the control group. The control group received captopril treatment

25 mg/time

three times/d. And the observation group was received Tangmaikang particles 5 g

tid. combined with captopril treatment

25 mg

tid. BUN

SCr and 24 h urinary protein were observed after 4 weeks treatment. Result: Two groups of patients with BUN

SCr

24 h urinary protein in pre-treatment was no significant difference. After treatment 4 weeks

the observation group compared with the same group before treatment

efficacy was significant difference (P<0.05); the control group compared with the same group before treatment

24 h urinary protein was significant difference in external (P<0.05)

BUN

SCr

while improving

but not statistically significant; compared the two groups after treatment

the effect was significant difference (P<0.05). Conclusion: Tangmaikang particles combined with captopril on treatment of DN was better than captopril alone.