Objective: To explore antihyperglycemic

antihyperlipidemic

antihypertensive and anti-tumor effects of the cactus fruit polysaccharide extract(CPFP). Method: The diabetic rats were induced by STZ in SD rats

and randomly divided into model group

insulin group(10 U·kg-1·d-1)

high-dose group of CPFP(2.37 g·kg-1·d-1)

low-dose group of CPFP(1.58 g·kg-1·d-1). The CPFP were administrated daily via gavage for eight weeks. During the experiment

the blood glucose of rats were determined. Male SD rats were fed by hyper-fatty diet for 3 weeks in order to establish the hyperlipemia rat model. The hyperlipemia rats were randomly divided into model group

lovastatin group(3.0 mg·kg-1·d-1)

high-dose group of CPFP(2.37 g·kg-1·d-1)

low-dose group of CPFP(1.19 g·kg-1·d-1). Different dose of CPFP were administrated daily via gavage for 3 weeks. The blood lipoprotein of rats were determined. Fifty male spontaneous hypertension rats(SHR)at the age of 15 weeks were randomly divided into model group

captopril group(0.01 g·kg-1·d-1)

high-dose group of CPFP(2.37 g·kg-1·d-1)

middle-dose group of CPFP(1.58 g·kg-1·d-1)

low-dose group of CPFP(0.76 g·kg-1·d-1). Ten male Wistar rats were served as normal group. Different dose of CPFP were administrated daily via gavage for 9 weeks. The systolic blood pressure(SBP)of experimental rats was detected weekly. S180-tumor bearing mice were established and divided into model group

cyclophosphamide(CTX)group(0.02 g·kg-1·d-1)

high-dose group of CPFP(1.97 g·kg-1·d-1)

middle-dose group of CPFP(0.99 g·kg-1·d-1)

low-dose group of CPFP(0.49 g·kg-1·d-1). The CPFP were administrated daily via gavage for 10 days. Tumor inhibition rates were recorded. Result: Compare with model group

the content of blood glucose was remarkably decreased and the hypoglycemic rates were 54.08% and 44.73% respectively in high-dose and low-dose group of CPFP. The levels of TC

TG and LDL-C were decreased significantly(P<0.01)in high-dose and low-dose group of CPFP. The level of HDL-C was obviously increased in high dose group of CPFP(P<0.05). The SBP level of SHR in CPFP treatment groups was depressed notability

nevertheless the SBP level of SHR of model group was increased obviously comparing with normal group after 9 weeks. The tumor was inhibited in CPFP treatment groups. The tumor inhibited rates were 49.70%

31.13 in high-dose

middle-dose group of CPFP respectively after 10 days. Conclusion: CPFP could markedly decrease blood glucose in STZ-induced diabetic rats and decrease blood lipoprotein in hyperlipemia rats. CPFP showed effects on reducing blood pressure in SHR and certain anti-tumor.