Objective: To study the effects and mechanisms of dihydroquercetin against myocardial ischemic model induced by isoproterenol in rat. Method: The health SD rats were randomly divided into blank group

model group

three dose groups of dihydroquercetin. Myocardial injury model was induced by subcutaneous injection of isoproterenol (5 mg·kg-1). The electrocardiogram ECG was recorded

superoxid dismutase(SOD)

malondialdehyde(MDA)

creatine kinase(CK)

creatine kinase isoenzymes(CK-MB) and lactate dihydrogenase (LDH) in the blood were detected by ELISA

pathological changes of rat’s myocardial tissue were determined by hematoxylin-eosin(HE) stainning. Result: J point displacement in ECG was improved in dihydroquercetin group. Serum CK

CK-MB and lactate dihydrogenase(LDH) decreased significantly in dihydroquercetin group compared with those in the model group. SOD activity increased and MDA content lowered in myocardial tissue homogenate in dihydroquercetin group. Conclusion: Dihydroquercetin had an effective role to treat coronary heart disease by inhibiting myocardial tissue ischemia induced by ISO and protecting myocardial cells from injury.