Objective: To study on preparation and drug release behavior in vitro of medicine loaded polyvinyl alcohol(PVA)fibrous membrane. Method: The micro-fibers of 2-SeCD/PVA were prepared by electrospun technique

whose relative weight percentage was 10%

20%

30% and 40% respectively. The structure and property of medicine loaded micro-fibers with different weight percentage were characterized by FT-IR and SEM. Drug release behavior in vitro of medicine loaded micro-fibers were investigated by ultraviolet-visible spectrometer in artificial intestinal fluid and artificial gastric juice. Result: The diameter of medicine loaded fibers became larger with increasing 2-SeCD content

however

the grown of accumulative released medicine curve was slower.The cumulative drug release percentage was higher in the simulated intestinal fluid than in the gastric juice with the same volumn percentage of 2-SeCD/PVA micro-fibers. Conclusion: Medicine loaded micro-fibers had better effective sustained-release and certain targeted drug delivery.