Oridonin

named isodonal and rubescensin A

can be achieved by alcohol extraction

extraction

chromatography and crystallization from the herba of Rabdosia rubescens. Oridonin is able to kill and inhibit different types of cancer cells

such as leukemia

breast cancer

melanoma and so on. Therefore

it’s widely used as anti-humor

antibacterial

anti-inflammatory and antinociceptive agent nowadays. However

due to its poor water-soluble and extremely bitter taste

the clinical application of oridonin is limited. Nanoparticle formulation

a new kind of drug delivery system

could improve its water-soluble and bioavailability effectively. Nanoparticles

liposomes

microemulsion

polymer micelles and nanosuspensions of oridonin have been developed during these years. This paper mainly reviews the latest research and application in nanoparticle formulation of oridonin. It will provide foundation for further research and development of new formulation for oridonin.