Objective: To explore the effects of Shenlong Jiannao capsule on the expression of choline acetyl transferase(ChAT) in hippocampus of cerebral ischemia rats. Method :Two-vessel occlusion were adopted to reproduce the cerebral ischaemia animal model.Rats were randomly divided into 5 groups as following: sham operation group

model control group

positive control group with pisacetam

Shenlong Jiannao capsule groups(low and high dosage). Shenlong Jiannao capsule groups low and high dosage treated by gavage with Shenlong Jiannao capsule at the dosage of 0.4

1.2 g·kg-1·d-1. After 28 days

changes of neurological scores and pathological tissue sections of brain in rats were observed

immunohistochemistry were adopt used to assay the expression of ChAT in hippocampus of cerebral ischaemia rats. Result: Shenlong Jiannao capsule could improve the neurological scores

ameliorate the morphology and increase the number of ChAT immunoreactive positive neurons.Comparing to model control group

the neurological scores were improved(P<0.05)

the expression of ChAT was increased in Shenlong Jiannao capsule group(P<0.01

P<0.05). Conclusion: Shenlong Jiannao capsule can ameliorate the cerebral injury involved in enhancing the ChAT protein expression.