The theory of intranasal brain-targeting system and its preparations were sumarized to provide basis for traditional Chinese mediline (TCM). literatures searching were based on keywords as intranasal administration

nasal administration and brain-targeting system. The paper not only described the nasal cavity physiological characteristics to study the transport mechanisms of intranasal drug delivery for brain targeting

but also reviewed the situation of the central nerve system disease treatment using the intranasal drug delivery for brain targeting. The paper also described the new intranasal formulation (in situ gel

liposomes

microspheres

nanoparticles formulations)and traditional Chinese medicine nasal administration to understand the process of traditional Chinese medicine nasal administration. Intranasal brain-targeting preparations of TCM had broad development prospect.