Objective: To observe the therapeutic effect of Ziyin Jianghuo Fang(ZYJHF) on patients suffering from menopausal syndrom (MPS) caused by deficiency of yin and exess of fire

try to explore its potential mechanism. Method: Sixty cases with MPS caused by deficiency of yin and exess of fire were randomly divided into two groups. The therapy group(30) was treated by ZYJHF

the control group(30) was treated by placebo A course lasted for 4 weeks

and total treatment was 3 courses. Result: The main symptom:flush

sweating in the therapy group was relieved(P<0.05)

while in the control group the symptom was not relieved. In the two groups

the Kupperman scores of and traditional Chinese medicine(TCM) symptom were decreased significantly(P<0.05)

but with significant difference in the two groups(P<0.01). Conclusion: ZYJHF could relief the clinical symptoms of MPS

particularly effective on hectic fever and perspiration

it can improve the life quality of patients suffering from MPS caused by deficiency of yin and exess of fire.