Objective: To observe the effect of Juantongyin (JTY) on microvessel density(MVD) and antiangiogenesis in ectopic endometrium of rats. Method: To observe the effect of high-dose

middle-dose

low-dose JTY and danazol on MVD of endometriotic rats through setting up endometriosis model with rat self-endometria transplantation. Sixty rats were divided into 6 groups randomly:JTY high-dose group (42.9 g·kg-1)

middle-dose group (14.3 g·kg-1)

low-dose group (4.8 g·kg-1)

and danazol group (0.021 5 g·kg-1)

model group and control group (10 mL·kg-1) of saline. Result: There was a marked diversity among model group(89.23±26.27) mm3 and other groups(32.96±15.38)

(15.75±8.36)

(38.16±17.32)

(42.91±19.54) mm3 (P<0.05) of the ectopic tissue volume. There was a marked diversity among model group(26.43±6.75)

and other groups (18.61±5.89

12.24±4.82

14.36±4.13

16.53±4.56)

(P<0.05) of the expression of MVD. Conclusion: JTY has inhibitory effect on the expression of MVD and angiogenesis in ectopic endometrium of rats

in a dose-dependent manner. JTY may be a new drug of antiangiogenesis in ectopic endometrium.