Objective : To study the antibacterial effect of Scrophulariae Radix particle in infected mice. Method : Staphylococcus aureus and Pseudomonas aeruginosa were cultured for 18 hours and then 5% yeast liquor was added each of them to a suitable level which made 80%-100% infected mice death. Then each of the suitable bacterial liquor was inoculated into the abdominal cavity of mice who had given corresponding medicines for 7 days. Death rate and average survival time were both observed and analyzed within 7 days after infected. Result : 3.5

2.8

2.1

1.4 g·kg-1 of Scrophulariae Radix particle and 3.5 g·kg-1 dose of conventional processed product can inhibit the death rate caused by S. aureus in mice and extend the average survival time; 3.5

2.8 g·kg-1 Scrophulariae Radix particle and 3.5 g·kg-1 dose of conventional processed product can inhibit the death rate caused by P. aeruginosa in mice and prolong the average survival days. Conclusion : Directly administrated Scrophulariae Radix particle has the equivalent antibacterial activity with conventional processed products.