Objective: To optimized the preparation technology of Euphorbia Humifusa Herba dropping pills. Method: Used appearance quality as evaluation criteria

investigated factors by using orthogonal design.The factors included ratio of drug to matrix

length of condensation pole

inside diameter of burette and so on. Result: Optimum technology of dropping pills was as follows: matrix was a mixture of polyethylene glycol 4000 and polyethylene glycol 6000(1 ∶7)

ratio of drug to matrix was 1 ∶3 at temperature of (82±2) ℃

condensate was dimethicone at (1-3) ℃

length of condensation pole was 15 cm

inside diameter of burette was 3.0 mm

dropping speed was 30 drops per minute. Conclusion: The prescription and preparation technology were reasonable and simple

Under above preparation process

appearance quality of dropping pills was fine

and subtle difference among pill weights.