Objective: To observe the changes of small intestines movement and motilin

substance P(SP) levels of rats with functional dyspepsia

to discuss the mechanism. Method: The animal model of functional dyspepsia was established by irregular feeding and stimulating tails of the rats. Forty-eight Wistar rats were randomized into control group

madinglin group

high

middle and low dose groups of shuweifang and modle group

8 rats in each group. The content of motilin and substance P in plasma were determined by radiommunoassay. And advance rate of small intestines were observed with phenolsulfonphthalein. Result: Compared to the control group

the contents of Motilin(MTL)

SP and advance rate of small intestines in model group were obviously decreased(P<0.05)

while in the Shuweifang and Madinglin group increased significantly(P<0.05). Conclusion: Shuweifang can increase the contents of MTL and SP in the plasma of model rats and promote advance rate of small intestines which is probably one of the mechanisms in the treatment of functional dyspepsia.