Objective: To observe the hypoglycemic and hypolipemic effects of Zhuyu Wan on experimental type 2 diabetes in rats. Method: One hundred and ten Wistar rats were divided randomly into normal experimental group (50 rats)

and diabetes experimental group (60 rats). The type 2 diabetic model was established through high fat diet and administration of Streptozotocin (30 mg ·kg-1 ip). After 7 days

50 rats were selected from the diabetes group. The selected 50 diabetic rats were randomly divided intothe following groups:model group (ig normal saline)

metformin group (ig metformin hydrochloride 0.2 g ·kg-1)

three Zhuyu Wan groups (ig 0.75

1.5

3 g ·kg-1 accordingly). Another 50 normal rats were divided similarly as the above diabetic rats

except the model group was replaced by a normal control group. All the rats were treated accordingly for two weeks. Then

effectiveness was evaluated by determinations of body weight

blood glucose and blood lipid. Result: Zhuyu Wan showed an obvious effect on lowering the blood glucose level in type 2 diabetes rats (P<0.01)

but it had no distinct effect on the blood glucose level for the normal rats. Zhuyu Wan could improve glucose obviously(P<0.01)

decrease the index on TC and TG

and delay the weight loss in diabetic rats (P<0.01). Conclusion: Zhuyu Wan can lower blood glucose

and regulate blood lipid and weight loss in type 2 diabetic rats.