ZHU Jian-wei, YAN Xue-sheng, LIU Jin. Effect of Cinnamon on Strychnos Studied by Sequential Acute Toxicity Test[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 245-247.
ZHU Jian-wei, YAN Xue-sheng, LIU Jin. Effect of Cinnamon on Strychnos Studied by Sequential Acute Toxicity Test[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 245-247.DOI:
Objective: To study the attenuated effect of cinnamon on strychnos. Method: The mice were administrated with strychnos decoction or strychnos-cinnamon decoction (strychnos ∶cinnamon=1 ∶5) intragastrically. The half lethal dose (LD50) of both decoctions were studieded and compared by the sequential acute toxicity test. Result: LD50 of the two decoction were strychnos decoction=(173.161±18.289) mg·kg-1
strychnos-cinnamon decoction=(781.345 ± 214.744) mg·kg-1. In addition
the average time from poisoning to death of the mice administrated with strychnos-cinnamon decoction was significantly longer than that of mice with strychnos deconction. Conclusion: Cinnamon can reduce the toxicity of strychnos significantly.