HU Ying-jun, ZHANG Jin-chao, WANG Lan, et al. Regulation of Lipid Metabolism and Vascular Endothelial Function by Soft Capsule of Yindan Xinnaotong in Hyperlipidemia Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 162-164.
HU Ying-jun, ZHANG Jin-chao, WANG Lan, et al. Regulation of Lipid Metabolism and Vascular Endothelial Function by Soft Capsule of Yindan Xinnaotong in Hyperlipidemia Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 162-164.DOI:
Objective: To observe the effects of Soft Capsule Yindan Xinnaotong on regulation of lipid metabolism
antioxidation
vascular endothelial function in rat with hyperlipidemia. Method: Using hyperlipidemia animal model replicated by hyperlipidemia forage for 7 days
Yindan Xinnaoto capsule at doses of 2.25
0.45 g·kg-1 ig for 1 month was treated. The serum TC
TG
HDL-C
LDL-C lever were detected
the levels of malondial-dehyde(MDA)
superoxide dismalase(SOD)
nitric oxide(NO)
endothelin-1(ET-1) were assayed. Result: The levels of TG
TC
LDL-C
MDA and ET-1 in soft capsule of Yindan Xinnaotong treated groups were significantly reduced compared with model group. Conclusion: Soft capsule of Yindan Xinnaotong regulated the lipid metabolism
improved vascular endothelial function
increased the activity of scavenging free radicals in rat with hyperlipidemia.