Objective: To study the different purgative effect among different extracts of processed Rhez Radix et Rhizoma (Rhez Radix et Rhizoma

Rhez Radix et Rhizoma wine

cooked Rhez Radix et Rhizoma and Rhez Radix et Rhizoma carbon extracts). Method: The different samples were administered to mice for examining the purgative ED50 and observing the first purgative time

the 5 hour purgative times and defecation quantity;the effects on small intestinal propulsion were determined by charcoal powder rates in mice;the effects on Na+-K+-ATPase in rat colon wall cell membrane were determined after the rat was administered for 5 days. Result: The purgative ED50 of Rhez Radix et Rhizoma was equivalent to Rhez Radix et Rhizoma wine

the cooked Rhez Radix et Rhizoma and Rhez Radix et Rhizoma carbon were not purgative. The mice would be purgative when administered Rhez Radix et Rhizoma and Rhez Radix et Rhizoma wine for 3 hours

but judging from the first purgative time and the 5-hour purgative times

the purgative effect of Rhez Radix et Rhizoma was greater than Rhez Radix et Rhizoma wine. Compared with control group

the high dose of Rhez Radix et Rhizoma

the Rhez Radix et Rhizoma wine and the low dose of Rhez Radix et Rhizoma carbon could significantly promote the small intestinal propulsion in mice

but the cooked Rhez Radix et Rhizoma and the low dose of Rhez Radix et Rhizoma carbon could not. The four processed products of Rhez Radix et Rhizoma can inhibit Na+-K+-ATPase in rat colon wall cell membrane

but the Rhez Radix et Rhizoma showed the best inhibitory effect. Conclusion: The four extracts of processed Rhez Radix et Rhizoma have different purgative effects. The Rhez Radix et Rhizoma was the best

next came the Rhez Radix et Rhizoma wine

and the cooked Rhez Radix et Rhizoma and Rhez Radix et Rhizoma carbon were poor.