Objective: To research the regulation of Jiangfang Baoxin capsule to vascular endothelial cell function disorder in essential hypertension patients. Method: Sixty-two essential hypertension patients were rando mLy divided into two groups:control group(30 cases)and herb intervention group(32 cases)

which were treated with standard therapy and additional Jiangfang Baoxin capsule(orally ter daily

3 capsules each time)respectively for 3 months. The changes of blood pressure and levels of nitric oxide(NO)

nitric oxide synthase(NOS)

inducible nitric oxide synthase(iNOS)

endothelin(ET-1)and angiotention II(AngII)from peripheral blood of the two group patients were compared. Result: After treatment

NO level and NO/ET-1 ratio of herb intervention group was significantly increased than before(P<0.05)

while ET-1 dose significantly decreased(P<0.05)

and the levels of NOS

iNOS

ET-1 and AngⅡ had no difference;In control group

there was no difference of the values of NO

ET-1

AngII and NO/ET-1 ratio between before and after treatment

and the levels of NOS and iNOS were significantly decreased through the treatment(both P <0.01);After treatment

values of NO

NOS

iNOS and NO/ET-1 ratio of herb intervention were all significantly higher than those of control group(P<0.01). Conclusion: Jiangfangbaoxin capsule could correct (vascular endothelial cell

VEC) function obstacle and protect VEC function of essential hypertension patients.