白芍水提过程中芍药苷含量的NIRS快速测定研究

熊明华; 方少敏; 饶毅; 王信; 刘安; 田紫平

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白芍水提过程中芍药苷含量的NIRS快速测定研究

更新时间：2024-01-04

- 白芍水提过程中芍药苷含量的NIRS快速测定研究
- Study for Rapid Determination of the Paeoniflorin Content in Water Extracting Process of Paeoniae Alba by NIRS
- 中国实验方剂学杂志 2011年17卷第21期页码：52-56
- 作者机构：
- 作者简介：
- 基金信息：
  
  "重大新药创制"科技重大专项(2009ZX09313-030)
- DOI：
  中图分类号：
- 纸质出版日期：2011
- 稿件说明：
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熊明华, 方少敏, 饶毅, 等. 白芍水提过程中芍药苷含量的NIRS快速测定研究[J]. 中国实验方剂学杂志, 2011,17(21):52-56.

XIONG Ming-hua, FANG Shao-min, RAO Yi, et al. Study for Rapid Determination of the Paeoniflorin Content in Water Extracting Process of Paeoniae Alba by NIRS[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 52-56.
熊明华, 方少敏, 饶毅, 等. 白芍水提过程中芍药苷含量的NIRS快速测定研究[J]. 中国实验方剂学杂志, 2011,17(21):52-56. DOI：

XIONG Ming-hua, FANG Shao-min, RAO Yi, et al. Study for Rapid Determination of the Paeoniflorin Content in Water Extracting Process of Paeoniae Alba by NIRS[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 52-56. DOI：

摘要

目的: 基于近红外光谱(NIRS)技术的

建立白芍提取过程的快速质量控制方法。方法: 针对白芍提取过程

以HPLC测定提取液样品中芍药苷含量

同时采集其NIRS

采用偏最小二乘(PLS)回归法建立NIRS与HPLC分析值之间多元校正模型。结果: 校正模型的内部交叉验证决定系数 R2 为99.86

内部交叉验证均方差RMSECV为0.023 9。对提取过程中的白芍样本进行预测

结果令人满意。结论: NIRS可准确预测白芍提取过程中芍药苷含量

可推广运用于中药提取过程的快速、实时质量监控。

Abstract

Objective: To set up a novel method for fast quality control of Paeoniae Alba’s extracting process based on near infrared spectroscopy (NIRS). Method: Aiming at the process of extracting

the content of paeoniflorin was determined by HPLC as the reference values

and the NIRS data were collected

and then partial least square (PLS) regression was applied to build the calibration model of paeoniflorin. Result: RMSECV of the model for paeoniflorin was 0.023 9

the correlation coefficient of the prediction samples between the predictive value and the real value was 99.86. The calibration model was used for testing samples

and the results were satisfied. Conclusion: NIRS can accurately determine the content of paeoniflorin

and indicates potential to be widely used in the extracting process of traditional Chinese medicine.

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