Objective: To provide experimental data for technical improvement and quality standards by investigated the effect on transfer rate of chlorgenic acid from Flos Lonicerae (FL)

which is decocted with other medicinal herbs in Yinqiao Jiedu Keli. Method: Five medicinal herbs in Yinqiao Jiedu Keli were selected to decoct with FL. The herbal samples were consisted of FL group

FL with Semen Sojae Praeparatum group

FL with Fructus Arctii group

FL with Radix Platycodonis group

FL with Herba Lophatheri group

FL with Radix Et Rhizoma Glycyrrhizae group

FL with selected five medicinal herbs group. The contents of chlorgenic acid were determined by HPLC

and then used to calculate the transfer rate in each group. Result: The transfer rate of chlorgenic acid from FL decocted with other herbs decreased to a certain degree. Conclusion: The transfer rate of chlorgenic acid from FL was affected by mixed decoction with other medicinal herbs.