Objective: To observe the effects of ginseng panaxadiol saponins (PDS) on thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α(6-Keto-PGF1α) in rat model of endotoxic shock. Method: Sixty rats were divided into 6 groups randomly:groups under the names of lipopolysaccharides (LPS)

LPS+dexamethasone (DEX

2 mg·kg-1)

LPS+PDS (22.5 mL·kg-1)

LPS+PDS (45 mL·kg-1)

LPS+PDS (90 mL·kg-1) and control group respectively. PDS was injected into ranine vein ten minutes after septic shock model was induced by injection of LPS (4 mg·kg-1). MAP was measured through carotid arterial cannula. Animals were killed after 4 hours and their livers (20mg each) were taken for homogenate. PGF1α and TXB2 were measured using radioimmunoassay kit. Result: MAP in LPS group was decreased significantly after injection of LPS and maintained at lower level. While MAPs of LPS+DEX

LPS+PDS were not shown obviously decrease. PGF1α and TXB2 of LPS+PDS group were decreased obviously with comparison to LPS group. Conclusion: PDS plays the role of anti-shock through decreasing the levels of PGF1α and TXB2 in rats with septic shock.