Objective: To observe the therapeutic effect of the Shuxuening injection and Trimetazidine on coronary heart disease(CHD)and angina pectoris. Method: One hundred and twenty patients were randomly divided into treatment group and control group. The control group were given routine western medicine

and the treatment group received Shuxuening injection and trimetazidine additionally. 4 weeks was a course of treatment. Result: The total effective rate was 85.00% in control group and 98.33% in treatment group on the clinical symptoms(P＜0.05). The total effective rate was 60.00% in control group and 85.00% in treatment group on the electrocardiogram(P＜0.05).The total cholesterol (TC)

low density lipoprotein (LDL-C) and triglyceride (TG) of the two groups was significantly lowered

and high density lipoprotein (HDL-C) was highered

and improving in the treatment group was more significant than in the control group(P<0.05). Conclusion: Shuxuening injection and Trimetazidine has significant therapeutic effect in treating CHD and angina pectoris.