DIAO Yi-ping. Chemical Composition of Compound Ziling Capsule by UPLC-ESI-QTOF-MS-MS[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 64-68.
DIAO Yi-ping. Chemical Composition of Compound Ziling Capsule by UPLC-ESI-QTOF-MS-MS[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 64-68.DOI:
Objective: To analyze and identify the chemical components in compound Ziling capsule by ultra performance liquid chromatography-electrospray ionization-quadrupole time of flight/mass spectrometry (UPLC-ESI-QTOF-MS). Method: These compounds were analyzed with an ACQUITY UPLC BEH C18 (2.1 mm×100 mm
1.7 μm) by gradient elution using acetonitrile and 0.1% formic acid. ESI source was used and data were acquired in positive and negative mode. The running time was 20 min. Result: Thirty compounds in compound Ziling capsule were identified by positive and negative QTOF-MS-MS data analysis
the elemental compositions analysis
comparison with the standard substance and the literature values. Conclusion: It is a rapid and accurate method for tracing to source of compounds in compound Ziling capsule.