Objective: To study the effect of Cuscuta chinensis polysaccharide(CCP) on glucose-lipid metabolism in diabetic rats induced by streptozotocin. Method: The rat diabetic model was established by 50 mg ·kg-1 streptozotocin iv

10 days later the rats with fasting blood glucose beyond 11.1 mmol ·L-1 were selected as diabetic rats. Experimental groups (n=8

each) included model

CCP (400

200

100 mg ·kg-1)

acarbose 15 mg ·kg-1

and another normal control group was also setup. After ig treatment for 15 days

body weight

fasting blood glucose

glycosylated serum protein

insulin

blood lipid level in rats were measured to evaluate the effect of CCP. Result: In model group

body weight was significantly reduced(P<0.01)and levels of fasting blood glucose

glycosylated serum protein

CHO

TG were increased (P<0.01 or P<0.05)while insulin level was reduced(P<0.01)

compared with those in the normal control. CCP 200

400 mg ·kg-1 could significantly improve the weight loss of diabetic rats(P<0.05

P<0.01)

reduce fasting blood glucose and glycosylated serum protein(P<0.01 or P<0.05)

CCP 400 mg ·kg-1 could significantly reduce CHO level(P<0.05). CCP 400

200

100 mg ·kg-1 could significantly reduce TG level(P<0.01 or P<0.05). No obvious effect of CCP on insulin level was observed. Conclusion: CCP could improve glucose-lipid metabolism for the experimental diabetic rats.