Objective: To establish hyperlipidemia model of rats

to observe total saponins of Medicago sative(BD-TAS) on blood lipid metabolism in hyperlipidemia rats. Method : Sixty SD rats were randomly divided into six groups: normal control group (NC)

high-lipid model group (HC)

Xuezhikang capsule group

and BD-TAS group. All groups were induced with high fat diet for 8 weeks except NC

to establish hyperlipemia. NC and HC group were ig physiological saline

BD-TAS (4

9

12 g ·kg-1)

Xuezhikang Capsule group(0.5 g ·kg-1). The contents of TC

TG

LDL-C

HDL-C and MDA were examined four times in the plasma after 0

2

4

6 weeks. Result : The result showed that with high fat diet after 8 weeks

compared with NC group

TC

TG

HDL-C and LDL-C were increased significantly (P < 0.05)

so hyperlipidemia rat model was established successfully. BD-TAS of different dose groups

TC and TG in plasma were reduced after 2

4

6 weeks

compared with HC group (P<0.05). The level of TC in low-dose BD-TAS group was statistically significant compared with Xuezhikang group (P<0.05) and the levels of TC

TG in high-dose BD-TAS group were statistically significant compared with low-dose BD-TAS group (P<0.05). Conclusion : The levels of TC

TG and MDA decreased with the increased of BD-TAS dose

indicating a clear dose-effect relationship. BD-TAS is effective in modulating the blood lipid levels.