剂型因素和给药途径对人参皂苷Rg1在大鼠血清和脑组织中分布的影响

陈新梅

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剂型因素和给药途径对人参皂苷Rg1在大鼠血清和脑组织中分布的影响

更新时间：2024-01-04

- 剂型因素和给药途径对人参皂苷Rg1在大鼠血清和脑组织中分布的影响
- Experimental study on the effect of dosage form and administration route to the distribution of Ginsenoside Rg1 in serum and brain of the rats
- 中国实验方剂学杂志 2011年17卷第14期
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- 纸质出版日期：2011
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陈新梅. 剂型因素和给药途径对人参皂苷Rg1在大鼠血清和脑组织中分布的影响[J]. 中国实验方剂学杂志, 2011,17(14).

chen xin mei. Experimental study on the effect of dosage form and administration route to the distribution of Ginsenoside Rg1 in serum and brain of the rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14).
陈新梅. 剂型因素和给药途径对人参皂苷Rg1在大鼠血清和脑组织中分布的影响[J]. 中国实验方剂学杂志, 2011,17(14). DOI：

chen xin mei. Experimental study on the effect of dosage form and administration route to the distribution of Ginsenoside Rg1 in serum and brain of the rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14). DOI：

摘要

目的：考察剂型因素和给药途径对人参皂苷Rg1在大鼠血清和脑组织中分布的影响。方法：大鼠鼻腔给人参皂苷Rg1鼻腔喷雾剂，以大鼠口服和鼻腔给人参皂苷Rg1生理盐水为对照，给药后测定各组大鼠脑和血清中的人参皂苷Rg1的含量。采用Wagner-Nelson法处理数据。结果：鼻腔给药药途径使人参皂苷Rg1在血清和脑组织中的分布和转运效率分别提高了5.05和2.50倍；喷雾剂的剂型因素使人参皂苷Rg1在血清和脑组织中的吸收和转运效率分别提高了11.80和和3.35倍。结论：对人参皂苷Rg1，鼻腔给药途径和喷雾剂都能显著提高其生物利用度。

Abstract

Objective: To discuss the effect of dosage form and administration route to the distribution of ginsenoside Rg1 in serum and brain of the rats. Methods: Compared with ginsenoside Rg1 saline solution administrated from nasal route and oral route

ginsenoside Rg1 nasal spray was administrated from nasal route in rats. The concentration of ginsenoside Rg1 in the serum and brain was detected by HPLC-UV. The data was analysised by the Wagner-Nelson method. Results: The distribution and transport efficiency of ginsenoside Rg1 was improved 5.05 and 2.50 times respectively by nasal administration route. The distribution and transport efficiency of ginsenoside Rg1 was improved 11.80 and 3.35 times respectively by nasal spray. Conclusion: The bio-availability of ginsenoside Rg1 can be improved dramatically by the nasal administration route and nasal spray.

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