Objective: To observe the clinical effect of the self-control Liyan agents on the treatment for radiation esophagitis. Method: Sixty patients with lung cancer by radiotherapy were randomLy divided into two groups. The treatment group of thirty cases of beginning to end was given the self-control Liyan agents; thirty patients in the control group from beginning to end was given the common western medicine by mouth. Then evaluated any changes in the incidence of radiation esophagitis for the patients and T Lymphocyte subsets. Result: The incidence of radiation esophagitis in the treatment was 16.67%

and the control group’s incidence was 56.67%

there was significant differences between the two groups(P<0.05). After treatment the proportion of CD3+T cells

CD4+T cells

CD8+T cells and the CD4/CD8 ratio has statistical significance compared with those before treatment. And there was no change in the control group. Conclusion: Using the self-control Liyan agents could reduce the incidence of radiation esophagitis

improve the patients’ immunity

prevent certainly the emergence of radiation esophagitis.