objective: optimize of extraction technology for the saikosaponins from Bupleurum. Methods: The extraction technology for the saikosaponins from Bupleurum was optimized by adopting a single factor experiment and an orthogonal experiment with the use of the extraction rate of the saikosaponins from Bupleurum as the assessment index. Result: The optimized extraction technology for the saikosaponins from Bupleurum was as follows: the powder of Bupleurum with a diameter less than 355μm was subjected to reflux extraction for 2 times with 80% ethanol(regulate pH to 8) at 80 ℃

each extraction lasting 60min. For each extraction

the solvent to solid ratio is 8. Conclusion: the result showed that the extraction technology for the saikosaponins from Bupleurum simple

reliable

repeatable and suitable for production in industry.