复方全蚕粉胶囊对2型糖尿病大鼠糖、脂代谢的影响

曹育; 黄亦琦; 王梅兰; 杨辉; 樊希承; 黄颖; 罗友华

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复方全蚕粉胶囊对2型糖尿病大鼠糖、脂代谢的影响

更新时间：2024-01-04

- 复方全蚕粉胶囊对2型糖尿病大鼠糖、脂代谢的影响
- Influences of Compound Prescription Capsule of Silkworm Powder on Glycometablism and Lipid Metabolism in Type 2 Diabetic Rat
- 中国实验方剂学杂志 2011年17卷第14期页码：189-191
- 作者机构：
- 作者简介：
- 基金信息：
  
  厦门市卫生局科研基金项目(WSK2004Z-1)
- DOI：
  中图分类号：
- 纸质出版日期：2011
- 稿件说明：
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曹育, 黄亦琦, 王梅兰, 等. 复方全蚕粉胶囊对2型糖尿病大鼠糖、脂代谢的影响[J]. 中国实验方剂学杂志, 2011,17(14):189-191.

CAO Yu, HUANG Yi-qi, WANG Mei-lan, et al. Influences of Compound Prescription Capsule of Silkworm Powder on Glycometablism and Lipid Metabolism in Type 2 Diabetic Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 189-191.
曹育, 黄亦琦, 王梅兰, 等. 复方全蚕粉胶囊对2型糖尿病大鼠糖、脂代谢的影响[J]. 中国实验方剂学杂志, 2011,17(14):189-191. DOI：

CAO Yu, HUANG Yi-qi, WANG Mei-lan, et al. Influences of Compound Prescription Capsule of Silkworm Powder on Glycometablism and Lipid Metabolism in Type 2 Diabetic Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 189-191. DOI：

摘要

目的: 观察复方全蚕粉胶囊对2型糖尿病大鼠糖、脂代谢的影响。方法 :采用高脂饲料喂养加小剂量链脲佐菌素(STZ)ip SD大鼠复制实验性2型糖尿病模型

按血糖值将模型大鼠随机分、模型组、复方全蚕粉胶囊低、中、高剂量组(0.5

1.0

2.0 g ·kg-1)、阿卡波糖组(3 mg ·kg-1)

另设正常对照组。给药6周后测定各组大鼠空腹血糖(FPG)、血清胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、血清丙二醛(MDA)、超氧化物歧化酶(SOD)

并计算胰岛素抵抗指数(Home-IR)。结果 :与模型组比较

复方全蚕粉胶囊各剂量组可使 FPG

LDL-C和MDA显著降低

而HDL-C 和SOD显著升高(P＜0.05或P＜0.01)

能有效地改善高胰岛素血症状态。结论 :复方全蚕粉胶囊能有效调节2型糖尿病大鼠糖、脂代谢紊乱

改善外周组织对胰岛素的敏感性

从而减轻2型糖尿病大鼠的胰岛素抵抗。

Abstract

Objective: To observe the influences of Compound Prescription Capsule of Silkworm Powder(CCSP) on glycometablism and lipid metabolism in type 2 diabetic rat. Method : Male Sprague-Dawley rat model of type 2 diabetes was induced by high-fat diet and low dose streptozotocin (STZ). Seventy-two model rats were separated according to plasma glucose levels into models

normal control group

model group

low dose group

middle dose group

high dose group and Acarbose tablets group. After 6 weeks

all animals were tested respectively the levels of fasting plasma glucose (FPG) and fasting insulin (FINS)

cholesterol (TC)

triglyceride (TG)

low density lipoprotein-cholesterol (LDL-C)

high density lipoprotein-cholesterol (HDL-C)

malonaldehyde (MDA)

superoxide dismutase (SOD). Result : Compared with model group. Low

middle and high doses of CCSP could remarkably lower the levels of FPG

FINS

LDL-C and MDA

obviously improve the Home-IR

SOD and HDL-C(P<0.05 or P<0.01). It had the amendment of high-insulin. Conclusion : CCSP can effectively adjust the glyco-lipid metabolim

thus to abate insulin resistance.

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