Objective: To investigate the pharmacodynamics of ginsenoside Rg1(GRg1)nasal spray. Method :Water maze was used to observe the ability of learning and memory in the mice administrated with GRg1 nasal spray(30 mg ·kg-1). Step-down test was used to observe the impairment of memory acquisition

memory consolidation and memory retrieval induced by scopolamine

NaNO2 or ethanol. Result: The time required to the safe area and the error times were shortened in the normal mice administrated with GRg1 nasal spray. The error number was decreased and the latency was extended by the treatment of GRg1 nasal spray in the model mice with impaired memory acquisition

memory consolidation and memory retrieval. Conclusion: The ability of learning and memory in normal mice and in model mice can be improved to different degrees after administration of GRg1 nasal spray.