Objective: To investigate formulating principle based on Miao nationality medicine theory of Tongbi Paizhuo proved recipe(TBPZ)

study the medicine efficacy to treat acute gouty arthritis. Method : Wistar rats were divided into groups (n=10 each) at random

the group is respectively normal

positive control medicine

TBPZ high dose (6 g ·kg-1)

TBPZ low dose (3 g ·kg-1) and model. Rat model of acute gouty arthritis was established by MSU intraarticular injection. Medicines were ig given separately for 5 days or 11 days according to experimental requirements. Toe swelling rate and serumuric acid level in rats were determined. Analgesic effect of the recipe was evaluated by mice stimulated with acetic acid or hot plate. Result : TBPZ high dose group and positive control medicine group could reduced toe swelling rate markedly (P<0.01)

the low dose could reduced toe swelling rate obviously (P<0.05). TBPZ high and low dose both could reduce the serumuric acid level markedly in acute gouty arthritis rat (P<0.01)

which proved recipe had analgesic effect significantly in mice stimulated by acetic acid or hot plate. Conclusion : TBPZ could significantly reduce the serumuric acid level and toe swelling rate in acute gouty arthritis rat

and has certain analgesic effect in mouse. Formulating principle

such as 'using vine to activating blood circulation’ and 'excrete zhuo and luan’ of Miao nationality medicine for treating thermal- rheumatic

can be used as a reference to treat gouty arthritis.