精元康胶囊对化疗致骨髓抑制小鼠骨髓细胞Bcl-2,Bax mRNA表达水平的影响

蒋立峰; 蒋士卿

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精元康胶囊对化疗致骨髓抑制小鼠骨髓细胞Bcl-2,Bax mRNA表达水平的影响

更新时间：2024-01-04

- 精元康胶囊对化疗致骨髓抑制小鼠骨髓细胞Bcl-2,Bax mRNA表达水平的影响
- Effect of Jingyuankang Capsule on Expression of Bcl-2, Bax mRNA in Bone Barrow Cells of Model Mice of Chemotherapy-induced Myelosuppression
- 中国实验方剂学杂志 2011年17卷第11期页码：216-219
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- 基金信息：
  
  国家"十五"科技攻关计划项目(2004BA719A09-0203);河南省自然科学研究项目(2010A360007)
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- 纸质出版日期：2011
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蒋立峰, 蒋士卿. 精元康胶囊对化疗致骨髓抑制小鼠骨髓细胞Bcl-2,Bax mRNA表达水平的影响[J]. 中国实验方剂学杂志, 2011,17(11):216-219.

JIANG Li-feng, JIANG Shi-qing. Effect of Jingyuankang Capsule on Expression of Bcl-2, Bax mRNA in Bone Barrow Cells of Model Mice of Chemotherapy-induced Myelosuppression[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 216-219.
蒋立峰, 蒋士卿. 精元康胶囊对化疗致骨髓抑制小鼠骨髓细胞Bcl-2,Bax mRNA表达水平的影响[J]. 中国实验方剂学杂志, 2011,17(11):216-219. DOI：

JIANG Li-feng, JIANG Shi-qing. Effect of Jingyuankang Capsule on Expression of Bcl-2, Bax mRNA in Bone Barrow Cells of Model Mice of Chemotherapy-induced Myelosuppression[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 216-219. DOI：

摘要

目的: 通过观察精元康胶囊对骨髓细胞Bcl-2

Bax mRNA表达水平的影响

以深入探讨该药的作用机制。方法: 实时荧光定量PCR检测骨髓抑制模型小鼠骨髓细胞表达Bcl-2

Bax mRNA的情况。结果: Bcl-2 mRNA的表达水平精元康胶囊组最高

Bax mRNA的表达水平精元康胶囊组最低

与模型组比较有显著差异

与空白组比较无明显差异。结论: 精元康胶囊能升高抗凋亡基因Bcl-2的表达

同时降低促凋亡基因Bax的表达

对骨髓细胞凋亡相关通路产生影响

可能是精元康胶囊对化疗致骨髓抑制影响的重要机制。

Abstract

Objective: To observe the effect of Jingyuankang capsule on the expression of Bcl-2

Bax mRNA in bone marrow cells of model mice of chemotherapy-induced myelosuppression and make a further study of the mechanism of the medicine. Method: Measuring the expression of Bcl-2

Bax mRNA in bone marrow cells of model mice of myelosuppression with real-time fluorescence quantitative PCR. Result: The Jingyuankang group had the highest expression of Bcl-2 mRNA and lowest expression of Bax mRNA

compared with the model group

the difference was significant

while compared with the control group

there was no significant differences. Conclusion: These results confirmed preliminarily that Jingyuankang capsule could increase the expression of the anti-apoptotic gene Bcl-2 and decrease the expression of proapoptotic gene Bax

through affecting the apoptosis-related pathway to prevent the blood cells from apoptosis caused by chemotherapy

this may be an important mechanism.of Jingyuankang capsule treating the chemotherapy-induced myelosuppression.

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