强心宁煎剂对慢性心力衰竭心肾阳(气)虚、血瘀水停证 患者血浆TNF-,IL-6的影响

王祺; 杨积武

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强心宁煎剂对慢性心力衰竭心肾阳(气)虚、血瘀水停证患者血浆TNF-,IL-6的影响

更新时间：2024-01-04

- 强心宁煎剂对慢性心力衰竭心肾阳(气)虚、血瘀水停证患者血浆TNF-,IL-6的影响
- Effect of Qiangxinning Jianji on Plasma Levels of TNF-α,IL-6 in Chronic Heart Failure Patients
- 中国实验方剂学杂志 2011年17卷第14期页码：264-266
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- 纸质出版日期：2011
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王祺, 杨积武. 强心宁煎剂对慢性心力衰竭心肾阳(气)虚、血瘀水停证患者血浆TNF-,IL-6的影响[J]. 中国实验方剂学杂志, 2011,17(14):264-266.

WANG Qi, YANG Ji-wu. Effect of Qiangxinning Jianji on Plasma Levels of TNF-α,IL-6 in Chronic Heart Failure Patients[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 264-266.
王祺, 杨积武. 强心宁煎剂对慢性心力衰竭心肾阳(气)虚、血瘀水停证患者血浆TNF-,IL-6的影响[J]. 中国实验方剂学杂志, 2011,17(14):264-266. DOI：

WANG Qi, YANG Ji-wu. Effect of Qiangxinning Jianji on Plasma Levels of TNF-α,IL-6 in Chronic Heart Failure Patients[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 264-266. DOI：

摘要

目的: 探讨强心宁煎剂对慢性心力衰竭(CHF)患者血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响。方法 :将68例CHF患者随机分为治疗组和对照组(每组34例)

治疗组在对照组常规西药治疗基础上加用强心宁煎剂。2组于治疗前后分别测定血浆TNF-α

IL-6水平

同时评估NYHA心功能分级。结果 :治疗后2组NYHA心功能分级均较同组治疗前改善(P<0.05)

且治疗组优于对照组(P<0.05);同时治疗组血浆TNF-α

IL-6水平明显下降

与对照组及同组治疗前比较差异显著(P<0.05)。结论 :强心宁煎剂能够降低CHF患者血浆TNF-α

IL-6水平

可作为治疗CHF有效药物之一。

Abstract

Objective: To investigate the effect of Qiangxinning Jianji on plasma levels of tumornecrosis factor alpha (TNF-α)

interleukin-6 (IL-6) in chronic heart failure (CHF) patients. Method :CHF patients were randomly divided into the treatment group and control group. Plasma levels of TNF-α and IL-6 were measured and NYHA class was evaluated at the 8th week of treatment. Result :NYHA class was markedly improved in two groups

it was significantly better in treatment group than those in the control group (P<0.05). As compared with the control group

in the treatment group; TNF-α and IL-6 were lower

the difference between groups and between before and after treatment were significant (P<0.05). Conclusion :Qiangxinning Jianji could lower plasma levels of TNF-α and IL-6

and is one of the effective drugs in improving cardiac function in patients with CHF.

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