DONG Fu-rong, LIU Li, CHEN Zhi-liang, et al. Release Profile of Zhibing in-situ Gel [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 29-32.
DONG Fu-rong, LIU Li, CHEN Zhi-liang, et al. Release Profile of Zhibing in-situ Gel [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 29-32.DOI:
Objective: To investigate the release profile of Zhibing in-situ gel (ZB-ISG)in vitro. Method: ZB-ISG was prepared by Carbomer
investigated the release behavior of imperatorin and isoimperatorinin vitro
and the results were fitted by weibull equation. Result: ZB-ISG had slowly-releasing effect and could continously release for 8h
and the release effect decreases with the increase of Carbomer. The study showed that all models fitted well with Weibull equation. Conclusion: The releasing mechanism of ZB-ISG is non-Fickian diffusionin vitro.