Objective: To study the inhibitory effect of LAMS on prostatic cancer growth in tumor-bearing mice. Method: Fourty C57 mice inoculated with RM-1 prostate cancer cells for 7 days were divided into 4 groups according to the tumor size:the model group (NS)

cyclophosphamide (CY) group (20 mg ·kg-1)

LAMS low and high dose groups (50

100 mg ·kg-1)

ig

once daily. After 14 days of treatment

the animals were killed. The subcutaneous sarcoma

thymus and spleen were separated and weighted. Inhibition rate

spleen index and thymus index were then calculated. Result: CY 20 mg ·kg-1 significantly inhibited the growth of tumor

the inhibition rate was 40.3%;LAMS(low and high dose) also showed significant inhibitory effect compared with the model group

the inhibition rates were 25.0% and 33.8%. CY could significantly inhibited the thymus index and spleen index in tumor-bearing mice

however

the effects of LAMS were not significant. Conclusion: LAMS have inhibitory effects on RM-1 in tumor-bearing mice

but do not affect the immune function. Furthermore

LAMS has no side effects on chemotherapy drugs such as CY.