大鼠肠道酶和菌群对人参皂苷Rg的代谢转化研究

陈新梅

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大鼠肠道酶和菌群对人参皂苷Rg的代谢转化研究

更新时间：2024-01-04

- 大鼠肠道酶和菌群对人参皂苷Rg的代谢转化研究
- Experimental Study on Metabolism and Bio-Transformation of Ginsenoside Rg by Intestinal Enzyme and Microflora in Rats
- 中国实验方剂学杂志 2011年17卷第11期页码：210-212
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- 纸质出版日期：2011
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陈新梅. 大鼠肠道酶和菌群对人参皂苷Rg的代谢转化研究[J]. 中国实验方剂学杂志, 2011,17(11):210-212.

CHEN Xin-mei. Experimental Study on Metabolism and Bio-Transformation of Ginsenoside Rg by Intestinal Enzyme and Microflora in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 210-212.
陈新梅. 大鼠肠道酶和菌群对人参皂苷Rg的代谢转化研究[J]. 中国实验方剂学杂志, 2011,17(11):210-212. DOI：

CHEN Xin-mei. Experimental Study on Metabolism and Bio-Transformation of Ginsenoside Rg by Intestinal Enzyme and Microflora in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 210-212. DOI：

摘要

目的: 考察大鼠肠道酶和菌群对人参皂苷Rg1(GRg1)的代谢转化作用。方法: 研究100 mg ·L-1的GRg1溶液在37 ℃人工胃液(pH 1.0)和人工肠液(pH 6.8)中的稳定性;考察大鼠ig GRg1后粪便和尿液中的GRg1代谢状况。结果: GRg1在人工胃液中2 h内100%降解;在人工肠液pH中4 h相对稳定(RSD＜1.5%);GRg1被大鼠肠道内酶和菌群代谢。结论: 为提高生物利用度

GRg1应选择非口服途径给药。

Abstract

Objective: To investigate the effect of metabolism and bio-transformation of GRg1 by intestinal enzyme and microflora in rats. Method: The stability of GRg1 in the artificial gastric juice and intestinal juice was tested.The metabolism and bio-transformation of GRg1 administrated orally in rats were studied. Result: GRg1 was degraded totally within 2 hours in artificial gastric juice.Meanwhile

GRg1 was stable in artificial intestinal juice.GRg1 was metabolized by intestinal enzyme microflora in rats. Conclusion: GRg1 should be administrated from other routes instead of oral route in order to improve the bioavailability.

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