Objective: To study the effect of Danlou tablet on myocardial Infarct size and MMP-2

MMP-9 and TIMP-1 protein expression in rats with acute isoproterenol-induced myocardial infarction. Method :Eighty male Wistar rats were randomly divided into 4 groups:① blank control group(normal saline 10 mL ·kg-1

n=20);② model control group(normal saline 10 mL ·kg-1

n=20)③Danlou large dose group(900 mg ·kg-1

n=20);④Danlou small dose group(450 mg ·kg-1

n=20).Each group of rats were randomly paired into 10 pairs

continuously ig 14 d. Except the blank control group

acute myocardial infarction models were induced by subcutaneous injection of Iso 15 mg ·kg-1 after 14 days of drug treatment. Pathological changes in myocardial

then myocardial infarct size and myocardial MMP-2

MMP-9

TIMP-1 protein expression In 1d and 7 d after injected ISO were investigated. Result: Compared with model group

Danlou could significantly reduce the extent of ischemic myocardial injury

reduced myocardial infarct size

reduce ischemic myocardial protein expression of MMP-2(42.10±6.58 vs 26.71±6.84

P<0.01)and MMP-9(43.37±8.78 vs 32.91±5.21

P<0.01)

however

TIMP-1 expression was not affected. Conclusion: Danlou tablet may reduce myocardial necrosis area

and promote infarct healing

prevention and treatment of early left ventricular remodeling by inhibiting+ MMP-2

MMP-9 protein expression;Danlou tablet has no significant effect on the expression of TIMP-1

suggesting the inhibition of MMP activity may not be achieved by TIMP.