Objective: To study the protective effect of Jiejiu Oral Liquid on ethanol-induced liver injure. Method: Sixty male KM mice were divided into 5 groups randomly:blank control group

model control group with hepatic injury group and three experimental groups (Jiejiu Oral Liquid 1.67

3.33

10.0 g ·kg-1 respectively). Ethanol was given to mice by oral gavage once in order to make the acute liver injury model at the end of experiment. The content of MDA and GSH in hepatic tissue was detected by kits accordingly. The content of TG in hepatic tissue was detected by automatic biochemistry analyzer and the pathological change of fat in hepatic tissue was determined. Result: The content of GSH in 3.33

10.0 g ·kg-1 groups was significantly higher than that of model control group. The content of MDA and TG was obviously decreased in 10.0 g ·kg-1 group

compared to that in the hepatic injury model control group ( P <0.05). The pathological change of fat in hepatic tissue in 3.33 and 10.0 g ·kg-1 groups was significantly less than that of model control group ( P <0.05). Conclusion: Jiejiu Oral Liquid has the function of protecting the liver from ethanol-induced injury.