Objective: To study the analgesic and anti-inflammatory effects

as well as acute toxicity of the Wuling Jianzhou pellet. Method: Writhing method and formalin test were used in mice to evaluate the analgesic effect.Xylene induced ear swelling in mice and formation of cotton ball granuloma in rats were adopted to investigate the anti-inflammatory effect.LD50was assessed in mice. Result: At the dose of 3.8

7.6 g ·kg-1

Wuling Jianzhou pellet significantly reduced the number of writhing induced by acetic acid (P<0.05)

as well as mouse ear swelling induced by xylene (P<0.01).In formalin test

pain of phase I but not phase Ⅱ

was reduced after administration of Wuling Jianzhou pellet at 3.8

11.4 g ·kg-1 (P<0.01).The formation of cotton ball granuloma was inhibited by Wuling Jianzhou pellet at 7.6 g ·kg-1 (P<0.05).The LD50of Wuling Jianzhou pellet was 148.4 g ·kg-1. Conclusion: Wuling Jianzhou pellet has significant analgesic and anti-inflammatory effects

and exhibits low toxicity.