Objective: The extraction process of Fuyajing effervescent tablet was optimized by central composite design-response surface method. Method: The main influential factors on extraction process included the quantity of ethanol

the concentration of ethanol and extraction time. The extraction conditions were evaluated by the yield of extract and the total content of polydatin and osthole. The response surface methodology was used to optimize the conditions of extraction. Result: The optimum condition of extraction was extracted 2 times for two hours with ten times amount of 60% ethanol. Conclusion: It is simple

convenient and high predictive to optimize the extraction process of Fuyajing effervescent tablet by central composite design-response surface method.